Monthly Archive for: ‘January, 2012’

Strategies in biomimetic surface engineering of nanoparticles for biomedical applications

Strategies in biomimetic surface engineering of nanoparticles for biomedical applications

 

Yong-kuan Gong and Françoise M. Winnik, Nanoscale, 2012, 4, 360.

Engineered nanoparticles (NPs) play an increasingly important role in biomedical sciences and in nanomedicine. Yet, in spite of significant advances, it remains difficult to construct drug-loaded NPs with precisely defined therapeutic effects, in terms of release time and spatial targeting. The body is a highly complex systemthat imposesmultiple physiological and cellular barriers to foreign objects.Upon injection in the blood stream or following oral administation, NPs have to bypass numerous barriers prior to reaching their intended target. A particularly successful design strategy consists in masking the NP to the biological environment by covering itwith an outer surfacemimicking the composition and functionality of the cell’s external membrane.